Oral Submucus Fibrosis (O.S.M.F.) is associated with juxtaepithelial inflammatory reaction followed by fibroelastic changes of lamina propria which leads to stiffness of oral mucosa. Semecarpus anacardium oil possesses antioxidant, anticancer and anti-inflammatory activity which is relevant for treatment of O.S.M.F. The in-vitro antioxidant, anti-mitotic, anti-proliferative and in-vivo anti-inflammatory and analgesic activity was evaluated for the pharmacological evaluation of oil. Then Hydroalcoholic Gel was formulated using Semecarpus anacardium oil to study its effect on O.S.M.F. The gel was prescribed to patients suffering from O.S.M.F. and parameters such as ulcer size, no. of ulcers and color of mucosa and opening of mouth were studied. The present findings revealed that the hydroalcoholic gel showed promising effects on different parameters of O.S.M.F.
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